Abstract Search

ea0041ep627 | Endocrine tumours and neoplasia | ECE2016

RSUME regulates tumorigenesis and metastasis in pancreatic neuroendocrine tumors

Wu Yonghe , Tedesco Lucas , Lucia Kristin , Schlitter Anna M , Esposito Irene , Auernhammer Christoph J , Theodoropoulou Marily , Arzt Eduardo , Stalla Gunter K , Renner Ulrich

The factors triggering pancreatic neuroendocrine tumor (PanNET) progression are largely unknown. Here we investigated the role and mechanisms of the sumoylation enhancing protein RSUME in PanNET tumorigenesis. Immunohistochemical studies showed that RSUME is strongly expressed in normal human pancreas, in particular in β-cells. RSUME expression is reduced in insulinomas and is nearly absent in other types of PanNETs suggesting a role in PanNET tumorigenesis. In human panc...

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ea0049ep692 | Obesity | ECE2017

Hydroxysteroid (17beta) dehydrogenase 13 knockout mice present with inflammation associated liver steatosis

Heikela Hanna , Adam Marion , Portius Dorothea , Maki-Jouppila Jenni , Mehmood Arfa , Adhikari Prem , Esposito Irene , Elo Laura , Zhang Fu-Ping , Ruohonen Suvi T , Strauss Leena , Foti Michelangelo , Poutanen Matti

: Hydroxysteroid (17beta) dehydrogenases (HSD17Bs) form a group of enzymes that are characterized by their sequence similarity at the active site, and their ability to catalyze the conversion between the weak 17keto- and the highly active 17beta-hydroxysteroids. To study the physiological role of HSD17B13, a lipid droplet associated protein, we characterized the phenotype of knockout (KO) mice deficient in HSD17B13 (HSD17B13KO). The data revealed normal serum sex steroid conce...

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Endocrine Abstracts

RSUME regulates tumorigenesis and metastasis in pancreatic neuroendocrine tumors

Hydroxysteroid (17beta) dehydrogenase 13 knockout mice present with inflammation associated liver steatosis

BiosciAbstracts